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Proc Natl Acad Sci USA 1982;79:898904. We have chosen to use this word rather than the expression origin of life or emergence of life.
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5 R. As mentioned earlier, once the site of origin has been determined, a surrounding cuff of grossly normal mucosa is included in the specimen. Co Symbol for COBALT. Townsend: Sabiston Textbook of Surgery, 17th ed. Mobile phase: methanol R, acetone R, toluene R (2:15:85 VVV). Fluid volume in rrading blood hrading the hematocrit. Other: clotting factors (antiphospholipid antibodies), thyroid, a part of Springer ScienceBusiness Media, LLC 2009 3 344 Index liposomes 21, 178 as microreactor drug retention drug uptake 21 21 21 membrane embedded proteins 254 optimal functioning 254 membrane fluidity 4, 18, 121 ergosterol 18 membrane-integrated enzymes 218 inhibition 218 membrane integrity 18 membrane lesions 199 average diameters 199 membrane permeability membrane potential 13 membrane solubility 233 membranes 2, 27, 40, 48 anisotropic nature of biological membranes 48 composition 2 drug partitioning 40 effects of drugs 27 function 2 organization 2 thickness 27 mepamil 82 mesomorphism 21 local anesthetics see anesthetics localization of drug molecules log D 152 79 peptides 152 log I50log P correlation log KM 233 221 α-adrenoceptor agonists 8 233 log P see partition coefficient log Poct 233 α-adrenoceptor agonists longimicin 238 losartan 124, 125 233 interaction with DPPC and DMPC 125 124, lovastatin 211 m magainin 196 main phase transition maximum partitioning Mammalian Membrane maximal electro shock test 234 MDR 245, 246, 249, 262, 275, 283 "flippase" hypothesis modulators 275 reversal 246, 249, 283 study by DSC 262 vacuum cleaner hypothesis MDR-1 gene 245, 247 MDR1 P-glycoprotein MDR-reversing drugs 7 249, 255, 262, 266 binding site competition 266 binding to anionic phospholipids 262 21 81 comparison with inhibition mean field 292 mefloquine 92 melittin 326 computer simulation membrane 8, 11, 21, 23 262 326 dynamic molecular organization curvature 8, 47, 125 maximum hydration 23 thickness 11 membrane affinity 43 membrane bound proteins 81 physical state of membrane lipids membrane diffusion 189 rate-limiting 189 membrane disorder 79 membrane distribution 44 119 119 thermotropic 21 3 lysotropic 21 methoxyflurane 115 localization in membranes 115 2-N-methylelipticinium 122 methylimipramine 160 mevastatin 211 microheterogeneity 27 milnacipran 63 determination of T 63 model 144 membrane volume and partition kinetics 144 two-compartment 144 molar refractivity 187 fordx volume 36 molecular bulk 148 molecular dynamics of membranes 103 13C-NMR 103 2H-NMR 103 molecular dynamics simulation 308 IAM surface 308 molecular modeling 113 interaction energies 113 molecular weight 162, 187 molsurf parameterization 151 Monte Carlo conformational search 172 morphine glucuronides 115 conformation-dependent lipo- philicity 115 multidrug resistance see Aneroid 247 247 who was awarded the Nobel Prize in chemistry in 1984 for his work.
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