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HO HO NH2 CHAPTER 13 Pharmacology of Dopaminergic Neurotransmission 189 HO OH O NH2 HO Dihydroxyphenylacetic acid (DOPAC) 3-Methoxytyramine MAO AD O HO COMT Major metabolite (excreted in urine) O OH O HO (HVA) Homovanillic acid FIGURE 13-3. ), Congress recognized that a low ROI was precluding industrys interest in exploiting the early successes in antitumor drugs (antifol aminopterin for acute childhood leukemia and methotrexate for uterine choriocarcinoma).
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